Flame Man is a Robot Master from Mega Man 6 originally created to generate a large amount of thermal power, which is also his energy source. Although it's an outdated power source, it gives him more stability than robots with solar energy. Flame Man is very punctual, as he has to refill his energy three times a day, which makes him very demanding for oil. He sports a turban and likes to take care of his beard. Flame Man was later modified so he can use his thermal energy for fire attacks, released in the form of a flamethrower on his arm.

In the First Annual Robot Competition, he was reprogrammed by Mr. X to help him conquer the world, but was defeated by Mega Man. He attacks by creating fire pillars with his Flame Blast and shooting fireballs. His weakness is the Wind Storm.

Blizzard Man  is a snow themed Robot Master from Mega Man 6. He was originally created to monitor the weather in the Antarctic, but later his meteorological equipment was exchanged for a machine able to produce artificial snow using the humidity in the air, which he can use to attack enemies by creating ice crystals in his Blizzard Attack. He can also attack by rolling at enemies. Blizzard Man likes skiing and has won three gold medals consecutively in the robot Olympics.

In the First Annual Robot Tournament, he was reprogrammed by Mr. X to help him conquer the world, but was defeated by Mega Man. After the events of Mega Man 6, he found work as a weather forecaster.

Plant Man is Robot Master from Mega Man 6 designed as a flower, which can be used as camouflage. He was originally created as a keeper of a botanical garden, and is said to be able to communicate with plants. Because of his popularity, he became the mascot of the garden. He's very sensitive and can get depressed easily.

After hearing of the First Annual Robot Tournament, he was modified for combat and equipped with the Plant Barrier, a weapon that creates a barrier of energy that takes on the appearance of spotted flower petals. In the tournament, he was reprogrammed by Mr. X to help him in his plan to conquer the world.

Tomahawk Man is a combat Robot Master from Mega Man 6 designed as a Native North American warrior. Unlike the other seven Robot Masters from Mega Man 6, Tomahawk Man was built purposely for the First Annual Robot Tournament. However, he was reprogrammed by Mr. X to help him conquer the world, and was defeated by Mega Man.

His main weapon is the Silver Tomahawk, which he can throw and hit a target 100 meters away (328 feet, miscalculated 30 feet in his English CD data), but it moves in a upward arch, leaving a safe area for the opponent. To compensate for this, he can also attack by firing feathers horizontally from his headdress.

Yamato Man is a combat Robot Master modeled after a samurai warrior. Although his armor appears to be heavy, it was made thin and as light as possible to improve his mobility, but reducing his defense. He has the Japanese spirit, and has great respect for Knight Man due to his valor and honor. Yamato Man's weapon is the Yamato Spear, which he uses to throw spear tips at enemies. However, he has a short stock of spear tips, and has to pick them up after use.

In the First Annual Robot Tournament, he was stolen and reprogrammed by Mr. X to help him conquer the world. His weakness is the Silver Tomahawk.

Knight Man is a Robot Master from Mega Man 6 designed to resemble a medieval knight, with his resistant spiked armour. He was created primarily for combat, with balanced attack and defense attributes, and it is said that he has defeated over 1000 robots in duel. Knight Man is equipped with the Knight Crush, a strong flail (sometimes called mace or morning star) with a long chain in his left arm which allows him to attack with huge power from great distances. In his right arm he holds a resistant knight's shield, allowing him to block almost all attacks from the front.

In the First Annual Robot Tournament, he was reprogrammed by Mr. X to help him conquer the world. Because of his spirit of chivalry and honor, Yamato Man has great respect for him, and ironically, his weakness is the Yamato Spear, due to its ability to go around his shield and pierce his armour.

Centaur Man also known as "Kentauros Man" is a Robot Master that originally worked in an old museum. After he heard about the 1st Annual Robot Tournament, he entered the competition to restore the museum with the prize money, but was reprogrammed by Mr. X.

In Mega Man 6, he's equipped with an arm cannon on his right arm whose shots spreads on impact, and his Centaur Flash has space distortion abilities, allowing him to temporarily halt time, although he has to consume a large amount of energy to activate it. He is weak to Knight Man's Knight Crush.

Wind Man is a air-themed Robot Master that was originally created to work in agriculture, helping in the harvest. He has a strong rivalry with Air Man. In the First Annual Robot Tournament, he was stolen and reprogrammed by Mr. X to help him in his plan to conquer the world.

With his weapon, Wind Storm, he can generate powerful winds that can reach a speed of 200m/s, which he uses to pull enemies, increasing the speed if damaged. Wind Man has jet engines in his feet that allow him to hover and move faster, which he also uses to attack by moving above the opponent to smash him with his weight. His weakness is the Centaur Flash.

Rounder is a flying enemy in Mega Man 5, which basically looks like a flying eye. They appear in groups of three at the end of the first stage from Proto Man's Castle, right before the boss gates. Rounders were supposed to attack enemies while moving around them, but as attack functions were forgotten to be installed, they just circle around Mega Man and interfere with his shots (which could be dangerous since it appears along with Subeils that also appear near the end of said stage). Rounders can also crash into Mega Man if he jumps before they begin to circle completely. They can be easily destroyed with the Mega Buster or Water Wave, but if ignored for a sufficient amount of time, they will eventually fly away.

Power Piston is the boss of the second Mr. X stage in Mega Man 6, and is located at the hallway's end. It stays attached to the right wall, moving up and down, and stomps it to make boulders fall down. The best weapon to hit it with is the Silver Tomahawk, however, it takes practice to aim it properly. The player can also use Blizzard Attack if they run out of Silver Tomahawk.

Metonger Z is the boss of the third Mr. X stage, and located in the boiler area's main boiler room. Its attack alternates between straight shots and bouncing bullets. In either case, the weak spot is the Met in the cockpit, and the best weapon is Blizzard Attack. It is based on the robot Mazinger Z.

Mr. X   is a fake persona of Dr. Wily's, which he used to mask his true identity in Mega Man 6. Mr. X is a mysterious billionaire of unknown origin that is the leader of the X Foundation. He financially supports the World Robot Alliance and is the sponsor of the 1st Annual Robot Tournament. In the beginning of Mega Man 6, he takes control of eight of the strongest Robot Masters in the final event of the tournament to help him conquer the world. Before being revealed to be Dr. Wily in disguise, Mr. X mentioned that he was the one who manipulated Dr. Wily into helping him take over the world.

Mr. X fights with a iron ball type machine called X Crusher that swings in the screen and shoots a purple ball that splits in two when it touches the floor, each part sliding a different direction. Mr. X seems to have motion sickness while using it. When the machine is destroyed, he flies out from it and reveals that he is really Dr. Wily before escaping to his Wily Castle.

Mechazaurus is a giant Brachiosaurus-like robot who is the boss of the first Wily Castle stage in Mega Man 6.

It attacks by spitting fireballs and shoots platforms from its chest. The weak spot is its eyes, but they can be hard to hit at times. If Mega Man is equipped with the Rush Power Adapter, he can charge up his punch to hit the platforms back at the Mechazaurus, dealing 1 point of damage each time. The player can also ride the platforms up and shoot its eyes with Yamato Spear, which is the Special Weapon that it takes the most damage from.

Tank CSII is the boss of the second Wily Stage of Mega Man 6, in the deepest part of the Frozen Storage Area. It rides on three wheels while shooting bullets and exploding bubbles at Mega Man. Wind Storm is the best weapon to use to defeat this boss; caution should be taken so as to avoid wasting Wind Storm on the bubbles.

Wily Machine is the name of the machines that Dr. Wily uses in the end of most games from the original Mega Man series. Most of them have Wily's flying saucer on them and have two forms of attack, with the second form's weak point being the cockpit and Dr. Wily himself. Starting with Mega Man 4, the Wily Machines have been followed up by an escape pod, named the Wily Capsule. Also, starting with Mega Man 4, Wily's Machines have had an unmistakable skull motif.

Wily Capsule is the teleporting escape pod that Dr. Wily rides and uses for combat after the destruction of his Wily Machine. First appearing in Mega Man 4, it is the final form of Wily in said game and onward, which torments Mega Man for the rest of the classic series. It was at its strongest in Mega Man 7. The version in Mega Man 5 is called Wily Capsule II, and in Mega Man 8 it's called Wily Capsule Great. In other appearances it is referred to simply as "Wily Capsule".